10 Medications That Cause Dry Mouth
Talk with Your Doctor, doctors

Over 400 medications can create dry mouth.

There are over 400 medications that can create the dry, parched feeling in your mouth referred to as "dry mouth." Most of these medications have an antiadrenergic / anticholinergic effect, meaning they block certain functions of your body's systems that help promote watery secretions from glands, like saliva. Studies say dry mouth can create problems with swallowing, chewing and dental decay. Familiarize yourself with a few commonly used types of medications that can lead to oral dryness.

Was this helpful? (2314)

Medically Reviewed By: William C. Lloyd III, MD, FACS | Last Review Date:

© 2018 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

View Sources

Medical References

  1. Epstein, Benjamin J, GUMS, John G. and Molina, Emerson. Newer Agents for the Management of Overactive Bladder. Am Fam Physician. 2006 Dec 15;74(12):2061-8.
  2. Hattori T, Wang PL. Calcium Antagonists Cause Dry Mouth by Inhibiting Resting Saliva Secretion. Life Sci. 2007;81(8):683-90. 
  3. Scully, C. Drug effects on salivary glands: dry mouth. Oral Diseases. 2003 July;9(4):165-76. http://onlinelibrary.wiley.com/doi/10.1034/j.1601-0825.2003.03967.x/full
  4. Lewis KS and Han NH. Tramadol: A New Centrally Acting Analgesic. Am J Health Syst Pharm. 1997;54(6):643-52. https://www.ncbi.nlm.nih.gov/pubmed/9075493
  5. Volz HP, Gleiter CH. Monoamine Oxidase Inhibitors. A Perspective on Their Use in the Elderly. Drugs Aging. 1998;13(5):341-55. http://www.ncbi.nlm.nih.gov/pubmed/9829163
  6. Drugs, Supplements, and Herbal Information. MedlinePlus, a service of the U.S. National Library of Medicine.