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A Physician's Perspective on the Side Effects of Lupus

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This content is created or selected by the Healthgrades editorial team and is funded by an advertising sponsor. The content is subject to the Healthgrades medical review process for accuracy, balance and objectivity. The content is not edited or otherwise influenced by the advertisers appearing on this page except with the possible suggestion of the broad topic area. For more information, read the HealthGrades advertising policy.


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W. Hayes Wilson, M.D. is a rheumatologist at Piedmont Hospital in Atlanta, Georgia.

I have the greatest passion for the topic of side effects because it occupies the greatest portion of my day and it is perhaps the most difficult topic to address. As a doctor, it is unfortunate that all I can do for my patients is to help them choose a reasonable treatment plan based on my clinical experience. I cannot predict exactly how this treatment plan will affect them, and sometimes medications have adverse effects. I have never prescribed a medication that I expected to cause a side effect, and I have never prescribed a medication that I expected not to work.

Side effects are things that can happen, not things that will happen; it is the difference between Possibility and Probability. It is possible that a patient will have a side effect; the chances, though, are very small – usually less than 5%. It is probable that the medication will help the patient – there's more than a 50% chance, since all medications have to prove a beneficial effect to be approved by the FDA.

W. Hayes Wilson, M.D. discusses lupus misconceptions, symptoms and lifestyle changes.

2017 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

While side effects are daunting, it can be gravely detrimental to the patient if he or she chooses not to undergo treatment because of what may possibly happen. I believe that anything strong enough to help you is strong enough to hurt you. But, I also believe that the definition of insanity is doing the same thing over again and expecting a different result. If you are not happy with your current state of health, then you should change something. This may mean that you must try a new medication, which comes with the risk of possible side effects. But the risk of a side effect is nowhere near the risk to your health if you choose not to take medical action.

The Fear of Side Effects

Why are we so afraid of side effects that we ignore necessary treatment? A major issue is that the information regarding side effects is unfiltered and overly broad. It is not for the benefit of the patient, but for full disclosure in a litigious society. The Federal Trade Commission (FTC) mandates that, in direct-to-consumer advertisements, pharmaceutical companies are required to spend equal time talking about side effects as they do beneficial effects. This "Fair Balance" act should encourage informed patients. Instead, side effects are described without any frame of reference.

In a study, there may be a minuscule difference between side effects felt by the placebo group and the medicated group, but even if that difference is statistically insignificant, it needs to be reported. For example, in a study testing an osteoporosis medication, 1,340 patients taking the placebo reported experiencing back pain, while 1,347 patients taking the medication also reported experiencing back pain. Because there were numerically more reports of back pain in the medicated group than in the placebo group, back pain had to be listed as a possible side effect. More women die from complications of osteoporosis than die from breast cancer, yet now women with osteoporosis may choose not to take a lifesaving medication in order to avoid possible back pain – back pain that is essentially as likely to occur when taking a placebo as it is when taking the prescription medication.

This full disclosure of side effects is a faith buster.  It would be easy to say, "suit yourself, don't take the medicine," but I have seen tragedies where patients missed an opportunity to possibly save their own lives.

The Consequences of Not Treating the Disease

I once treated a young woman suffering from severe lupus with kidney involvement.  Both her kidney doctor and I strongly suggested that she take chemotherapy to treat the extreme inflammation in her kidneys. She decided not to take the medication because she was concerned it would render her infertile. I explained to her that she had to be alive to have the chance to conceive a child and that her lupus was life-threatening. She would not change her mind and three months later she died from complications of her lupus. 

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© 2016 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

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