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Stopping and Restarting Biologic Medications for Psoriasis


Jane Soung

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Your doctor may have explained why biologics were right for your psoriasis before you started treatment. But is there ever a reason to stop taking a biologic? When should you talk with your doctor about changing treatment?

Reasons You Might Stop

In most cases, once you start a biologic, it’s best not to stop, since most of these medications don’t work as well when restarted. Remicade (infliximab) is an example of a biologic that is typically used only once, since it often isn’t as effective when restarted after a break. Enbrel (etanercept) is an exception and seems better suited for off-and-on use.

There are many treatment options for psoriasis, and they all come with risks and benefits. Ultimately, whether you treat with topical creams, light therapy, or medications, you and your doctor will decide the best treatment path together.

Medical Reviewer: William C. Lloyd, MD, FACS Last Review Date: Apr 13, 2016

2017 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

However, like other psoriasis treatments, biologics can work for a while and then begin to lose effectiveness or cause unwanted side effects. It’s not unlikely that you may need to ask your doctor about switching treatments periodically. 

Some of the main reasons you might stop taking a biologic include:

  • Failure to reach or to maintain an adequate response to the medication

  • Serious side effects

  • Pregnancy

  • Elective surgery

  • Vaccination

Getting Good Results

Getting a good response to biologic therapy varies widely—between 50 and 90 percent of patients experience positive results—and it varies by specific drug. The number of weeks before a significant positive response to a biologic occurs can range for each drug, as well.Several studies have shown that biologic therapies often work well for psoriasis patients during the first year of treatment.

Because of the gradual decreased response to biologics with time, your doctor may need to use a trial-and-error approach to find another biologic or combination of treatments that better controls your psoriasis.

Combination Therapy

Recent research has also shown that many people with psoriasis don’t get a good response with biologic treatment alone. Before you stop a biologic, your doctor may consider combining treatments to see if you get better results. Some research trials have shown that a combination approach with biologics and narrow-band ultraviolet B (NB-UVB) light therapy has led to a faster and better treatment response.

Studies of Enbrel (etanercept) with methotrexate have shown a much improved response compared to etanercept alone. Topical therapy and oral retinoids like Acitretin may be used in combination with biologics for improved results, too.

Pregnancy and Breastfeeding

Long-term animal studies with Enbrel (etanercept), Humira (adalimumab), and Remicade (infliximab) showed no evidence of harm to the fetus. Yet while the risk seems low, it’s still unknown what effect biologics may have on human pregnancy or on a nursing infant.

Because of the limited information, biologic drugs generally should be avoided in pregnancy. It’s generally thought that biologics should be avoided during breastfeeding, as well. However, there is limited evidence that Remicade (infliximab) is not excreted in breast milk.

It’s important to weigh the risks and benefits of taking biologics before, during, and after pregnancy with your doctors.

Prepping for Surgery

Whether and when you stop biologic therapy before elective surgery will depend on the specific drug that you’re on. It’s recommended that your biologic be stopped more than four half-lives before your surgery. A drug’s half-life is the time it takes for half the drug dose to be broken down into other substances in the body.

Each drug has a different half-life, so talk with your doctor to figure out when you need to stop your biologic before scheduling any elective surgery. Your biologic should be restarted after the procedure.

Vaccination Safety

People with psoriasis who are on biologic therapy should still receive the pneumococcal and annual influenza vaccines.

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Medical Reviewers: William C. Lloyd III, MD, FACS Last Review Date: Aug 7, 2017

© 2016 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

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Medical References

  1. Gniadecki, R. et al. Comparison of drug survival rates for adalimumab, etanercept and infliximab in patients with psoriasis vulgaris. British Journal of Dermatology. May 2011 Vol 164. pp. 1091–96.
  2. Mozzi, P et al. Psoriasis: an evidence-based update. Report of the 9th Evidenced Based Update Meeting. 12 May 2011, Loughborough, U.K. British Journal of Dermatology. Volume 166, Issue 2, pages 252–260, February 2012.
  3. Langley, R. Effective and sustainable biologic treatment of psoriasis: what can we learn from new clinical data? Journal of the European Academy of Dermatology and Venereology. Volume 26, Issue Supplement s2, pages 21–29, March 2012.
  4. Psoriasis Treatments. National Psoriasis Foundation.
  5. Conception & Pregnancy: Treatment with systemic. National Psoriasis Foundation.

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