Breakthroughs in Precision Medicine for Cancer

By

Erin Azuse

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DNA Magnification

Precision medicine is still a relatively new term to many people. This innovative approach to medicine tailors a patient’s treatment plan according to their unique characteristics, including genes, lifestyle, and environment. In the world of cancer care, this is important since we’ve seen how cancer can be very different from person to person, and some exciting progress has already been made.

Targeted therapies are a growing part of cancer treatment.

A newer form of cancer treatment, known as targeted therapy, is often considered the foundation of precision medicine. Researchers have found that  changes within the genes of cancer cells are what allow them to grow and divide uncontrollably. Just like the name implies, targeted therapies were developed to “target” those genetic changes and stop the cancer from progressing. Targeted therapies specifically attack the cancer cells while leaving healthy cells unharmed, as opposed to other treatments like chemotherapy which can damage healthy cells.

Some patients may now have genetic screenings performed on their cancer. If a genetic change is found that has a targeted therapy available, this may be added to their treatment plan. There are targeted therapies available for several types of cancer, including:   

  • Leukemia: Gleevac (imatinib) was the first FDA-approved targeted therapy for chronic myelogenous leukemia in the 1990s.

  • Breast cancer: Herceptin (traztuzumab) is used for HER2-receptor positive breast cancer.

  • Colorectal cancer: Drugs that block epidermal growth factor receptor (EGFR) protein may help slow the growth of colorectal cancer.

  • Lung cancer: Like colorectal cancer, blocking the EGFR receptor can help treat lung cancer.

  • Melanoma: Almost 50% of melanomas have a genetic mutation in the BRAF gene. Those that do can benefit form a BRAF-inhibitor drugs.

There are not currently targeted therapies for all types of cancer, and not all patients are eligible based on their cancer’s genetic makeup. However, as precision medicine continues to advance, researchers continue to seach for new genetic changes and develop targeted treatments.

Precision medicine is shifting the way cancer is treated.

For many years, cancer treatment regimens were largely based on where the cancer originated in the body and how far the disease had progressed. So, for example, two people with Stage IV lung cancer would often receive the same course of treatment. Yet, just recently, the FDA approved Keytruda (pembrolizumab) as the first cancer treatment to be used based on the cancer’s genetic makeup, regardless of where in the body it first occurred. Only those patients whose tumors have specific gene mutations, confirmed through medical testing, are eligible candidates for Keytruda.

This is just the start. There are currently many other clinical trials, called basket studies, underway to look at how cancer treatments work against different types of cancer that share the same genetic mutations. Researchers remain hopeful that just like Keytruda, this shift will provide countless patients with access to more effective cancer therapies.  

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Medical Reviewers: William C. Lloyd III, MD, FACS Last Review Date: Aug 25, 2017

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Medical References

  1. FDA approves first cancer treatment for any solid tumor with a specific genetic feature. U.S. Food and Drug Administration. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm560167.htm
  2. Personalized Cancer Prevention. American Cancer Society. https://www.cancer.org/latest-news/personalized-cancer-prevention.html
  3. Precision Medicine. Susan G. Komen. https://ww5.komen.org/BreastCancer/PrecisionMedicine.html
  4. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. U.S. National Library of Medicine, National Institutes of Health. https://www.ncbi.nlm.nih.gov/pubmed/26744449
  5. Understanding Pharmacogenomics. American Society of Clinical Oncology. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-pharmacogenomics
  6. Understanding Precision Medicine in Cancer Treatment. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/precision-medicine
  7. What is Personalized Cancer Medicine?. American Society of Clinical Oncology. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/...
  8. What is Personalized Medicine?. Dana-Farber Cancer Institute. http://blog.dana-farber.org/insight/2013/09/what-is-personalized-medicine/

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