Drugs and Foods That Interact with Thyroid Medications
Excerpted from a Harvard Special Report
The following medicines and therapies can influence the effectiveness of thyroid medicines in one or more of the following ways: by interfering with the absorption of thyroid hormone, by binding thyroid hormone to binding proteins, and by interfering with thyroid hormone metabolism.
- thalidomide and lenalidomide
- oral anticoagulants
- bile acid sequestrants, including cholestyramine,* clofibrate, and colestipol*
- slow-release niacin
- aluminum hydroxide antacids
- cation-exchange resins
- proton-pump inhibitors
- androgens/anabolic steroids
- dopaminergic drugs including bromocriptine and cabergoline
- glucocorticoids such as prednisone
- growth hormone
- anticonvulsants including phenytoin,* phenobarbital,* and carbamazepine*
- other antidepressants and antipsychotic agents, including clomipramine and quetiapine
- calcium carbonate
- ferrous sulfate (iron)
- iodine* (including kelp supplements)
- multivitamins (presumably because of iron and calcium content)
- espresso coffee
- antituberculous drugs (rifampicin, ethionamide)
- bisphosphonates taken orally, such as alendronate
- nonsteroidal anti-inflammatory drugs such as meclofenamic acid, mefenamic acid, phenylbutazone
- radiographic agents (such as contrast agents containing iodine)*
- salicylates (high doses of aspirin and salsalate)
- sulfonamides (acetazolamide, sulfisoxazole)
* These drugs can have a major impact on thyroid treatment.
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