11 FAQs About Melanoma Treatment


Denise Mann, MS

Was this helpful? (3)
This content is selected and managed by the Healthgrades editorial staff and is brought to you by an advertising sponsor.

This content is created or selected by the Healthgrades editorial team and is funded by an advertising sponsor. The content is subject to the Healthgrades medical review process for accuracy, balance and objectivity. The content is not edited or otherwise influenced by the advertisers appearing on this page except with the possible suggestion of the broad topic area. For more information, read the HealthGrades advertising policy.


Treatments for Advanced Melanoma

When melanoma reaches an advanced stage and begins to spread, getting the right treatment becomes very important.
Mohs surgery

Melanoma, the potentially fatal form of skin cancer, may be on the rise. About 73,870 new melanomas will be diagnosed in 2015, and about 9,940 people are expected to die from this cancer that same year, according to the American Cancer Society. But the good news is there have been a slew of new treatments approved in recent years that can help people with advanced melanoma live longer and better lives.

Learn more about treatment options with these 11 frequently asked questions.

1. Is melanoma curable?

Yes. When found early and treated, the cure rate for melanoma is nearly 100%.

2. How do you catch melanoma early?

Perform monthly skin self-exams and know what to look out for–asymmetrical moles with irregular borders, many colors and diameters of ¼ inch or greater. Check your scalp, feet, nails, and genital area as well. See your dermatologist yearly for a skin check, and always let him or her know if you spot any suspicious moles. It’s always better to be safe than sorry.

3. What are the current treatment options for melanoma?

Surgery to remove the melanoma is typically the first step. This can be followed by additional treatments based on the cancer’s stage. Other treatments include chemotherapy, which kills all fast-growing cells in the body as a means to remove all traces of the cancer and/or radiation, which use energy rays to kill cancer. Immunotherapy is a newer melanoma treatment that stimulates your immune system to recognize and destroy cancer cells.

Targeted therapies are also new. These are essentially heat-seeking missiles designed to disable very specific genetic mutations in some melanomas.

4. How will my doctor decide on my melanoma treatment?

Your doctor will make melanoma treatment decisions based on the stage of the skin cancer, which includes how deeply it has grown into your skin, whether or not it has started to spread to other parts of the body, as well as your overall health. Treating early-stage melanomas may involve surgery alone, while more advanced melanomas often require other treatments, such as chemotherapy, radiation, immunotherapy or targeted therapy.

5. What is Mohs surgery?

Mohs micrographic surgery is a specific form of skin cancer surgery. During Mohs surgery, your surgeon first removes the visible melanoma. Then he or she goes back to remove more layers of skin, one by one. Each layer is examined under the microscope to make sure that there are clear margins (no cancer cells left). This type of surgery has a high cure rate.

6. What is targeted therapy?

Targeted therapies are among the newest and most exciting developments in melanoma treatment. These drugs target genetic mutations that play a role in certain melanoma’s spread. They only work in individuals who have the specific mutation. For example, about half of all melanomas have changes in the BRAF gene. The following drugs are U.S. Food and Drug Administration (FDA) approved to treat melanoma driven by BRAF mutations:

  • Vemurafenib (Zelboraf®)

  • Dabrafenib (Tafinlar®)

  • Trametinib (Mekinist®)

MEK inhibitors, such as Trametinib, blocks the BRAF pathway at a different step. BRAF inhibitors are taken as pills.

7. What is immunotherapy?

Immunotherapy is another recently developed melanoma treatment. Immunotherapy agents help your immune system recognize and fight cancer. They include Ipilimumab (Yervoy®), given by IV, and Pegylated interferon, which is an injection. The FDA also approved the immunotherapy agents nivolumab (Opdivo®) and pembrolizumab (Keytruda®) for individuals who have tried the drug ipilimumab and have a BRAF gene mutation. Both of these drugs are given as shots.

8. Can targeted therapies be used together?

Yes, sometimes they can. For example, BRAF inhibitors and MEK inhibitors are used in combination to provide more effective, longer-lasting treatment for advanced melanoma. These drugs are not used at the same time as immunotherapy agents.

Was this helpful? (3)
Medical Reviewers: William C. Lloyd, MD, FACS Last Review Date: Apr 29, 2015

© 2016 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

You Might Also Like

Breakthroughs in Treating Advanced Melanoma

Advanced melanoma is difficult to treat, but new treatment options like targeted therapy offer patients good news.

Share via Email


10 Melanoma Myths


When Melanoma Spreads to the Lymph Nodes