How Safe Are Biologics for Rheumatoid Arthritis?

By

Cindy Kuzma

Was this helpful? (4)
This content is selected and managed by the Healthgrades editorial staff and is brought to you by an advertising sponsor.
x

This content is created or selected by the Healthgrades editorial team and is funded by an advertising sponsor. The content is subject to the Healthgrades medical review process for accuracy, balance and objectivity. The content is not edited or otherwise influenced by the advertisers appearing on this page except with the possible suggestion of the broad topic area. For more information, read the HealthGrades advertising policy.

ADVERTISEMENT

Combination Therapy for RA

Treating RA early and aggressively could mean taking more than one RA drug at the same time, a process known as combination therapy.
Are Biologics for Me?

If you see a rheumatologist for your rheumatoid arthritis, there’s a good chance you’re taking a medication called a biologic response modifier. About 40 to 45 percent of patients that rheumatologists treat for RA take one of these drugs.

They’re called biologics because they’re made from a living organism, rather than being produced from chemicals in a lab. And although they don’t cure RA, they are highly effective in controlling the symptoms and preventing further joint damage. They produce a response in about two-thirds of the people who take them, often sending their disease into remission.

However, because they work by changing the way your immune system works, they do pose some serious risks. Since biologic agents were first approved to treat RA in the late 1990s, doctors have learned a lot about who’s most prone to these adverse effects and how to minimize them, says James R. O’Dell, MD, a rheumatologist and professor at the University of Nebraska Medical Center in Omaha and president of the American College of Rheumatology.

Understanding these threats—and working with your doctor to watch out for them—can help you safely get the benefits of these medications.

Infection Risk

Though there are several types of biologic agents that work in slightly different ways, they all change the way your immune system responds to perceived threats inside your body.

“We all know the immune system is supposed to protect us from infections,” says Dr. O’Dell. “So if we modify it too much, we have to be concerned about infections.”

Bacterial, viral, and fungal infections may be more common among people taking a type of biologic called a tumor necrosis factor (TNF) inhibitor. These medications, which include adalimumab (Humira) and infliximab (Remicade), work by blocking the action of TNF, a compound in the body that causes inflammation.

Other types of biologic agents have been linked to different infections. For example, people may be prone to hepatitis when taking rituximab (Rituxan). This drug binds to and destroys parts of the immune system known as T cells.

Your doctor will probably test you for these diseases before prescribing a biologic agent. Be sure to tell him or her if you have a history of serious lung, skin, or other type of infection; if you commonly develop skin ulcers or sores; if you live or have ever lived in areas where severe fungal infections are more common; or if you frequently travel to countries where tuberculosis and similar illnesses are common.

Cancer Risk

The immune system plays another important role in our bodies—that of surveillance system against malignancy. “All of us produce cells that could become cancers, but for the most part our immune system gets rid of them before anything bad happens,” says Dr. O’Dell. So when doctors first began testing biologic agents, they were concerned that people taking them would be at higher risk for cancer.

If you have RA, you already have an elevated risk for certain types of lymphomas, or cancers of the immune system. Your odds may increase again when you first began taking a biologic agent, particularly a TNF inhibitor. However, with time your risk goes back down and may even decrease, Dr. O’Dell says.

There also appears to be a slightly increased risk of skin cancer in some patients and lung cancer in patients who have other risk factors for the disease. These include smoking, exposure to hazardous chemicals, or previous radiation therapy. “Other more common malignancies—such as breast cancers and colon cancers—have not been a major concern,” Dr. O’Dell says.

Discuss the Risks with Your Doctor

Make sure you understand the potential risks of biologic agents before adding them to your treatment plan. Your doctor may suggest you take certain precautions before you begin taking these drugs. For instance, because vaccines that contain live viruses are risky for people with altered immune systems, you might get shots for diseases such as shingles before taking a biologic agent.

Was this helpful? (4)
Medical Reviewers: William C. Lloyd III, MD, FACS Last Review Date: Jul 29, 2015

© 2016 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

View Sources

Medical References

  1. Drug Guide: Biologics, D.R. Siegfried, Arthritis Foundation (http://www.arthritistoday.org/treatments/drug-guide/types-of-drugs/drug-guide-biologics.php);
  2. Lung Cancer Risk Factors, Centers for Disease Control and Prevention, Dec. 14, 2011 (http://www.cdc.gov/cancer/lung/basic_info/risk_factors.htm);
  3. Anakinra, National Library of Medicine, National Institutes of Health, Feb. 1, 2009 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a602001.html);
  4. Adalimumab Injection, National Library of Medicine, National Institutes of Health, Jan. 15, 2012 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a603010.html);
  5. Infliximab Injection, National Library of Medicine, National Institutes of Health, Jan. 15, 2012 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604023.html);
  6. Abatacept Injection, National Library of Medicine, National Institutes of Health, Feb. 11, 2012 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a606016.html);
  7. Rituximab Injection, National Library of Medicine, National Institutes of Health, March 1, 2010 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a607038.html);
  8. Golimumab Injection, National Library of Medicine, National Institutes of Health, Jan. 15, 2012 (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a610010.html);
  9. Rheumatoid Arthritis, U.S. National Library of Medicine, National Institutes of Health, Feb. 14, 2011 (http://www.nlm.nih.gov/medlineplus/ency/article/000431.htm);

You Might Also Like

Share via Email

PREVIOUS ARTICLE:

What Causes Joint Damage in Rheumatoid Arthritis?

NEXT ARTICLE:

8 Ways to Live Well With Rheumatoid Arthritis