Coping with Side Effects From Immunotherapy for Lung Cancer


Erin Azuse

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For patients with advanced lung cancer, immunotherapy is emerging as an exciting new treatment beyond the traditional radiation and chemotherapy route. Just as your immune system protects your body by destroying harmful bacteria and viruses, immunotherapy triggers your immune system to fight cancer cells.

Though immunotherapy is generally well tolerated, patients can still experience side effects from treatment. If you’re currently undergoing immunotherapy, here are some things you can do to help minimize these reactions.

Immunotherapy can offer a durable, long-term response to therapy for patients with lung cancer.

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Educate Yourself

It’s important to have a discussion with your medical team about what type of side effects you may experience, so you’re able to recognize them if they occur.  Though these can differ from person to person and vary based on the type of medication used, common side effects include:

  • Fatigue

  • Skin rash

  • Flu-like symptoms (fever, chills, nausea)

  • Decreased appetite

  • Joint pain

  • Decreased blood pressure

A small percentage of patients experience more serious side effects. Some examples are:

  • Pneumonitis (inflammation of the lungs)

  • Colitis (inflammation of the large intestine)

  • Thyroid problems

  • Hepatitis (inflammation of the liver)

  • Pancreatitis (inflammation of the pancreas)

Keep in mind it may take 6 to 12 weeks for side effects to appear, as opposed to treatments like chemotherapy where it’s often experienced much sooner.  Side effects may continue to occur even after treatment has stopped.

Report Immediately

The good news is when side effects are addressed early, they can often be resolved easily, so it’s imperative to let your doctor know if anything is troubling you. Frequently, your doctor will prescribe steroids or antihistamines to settle the inflammation and relieve your symptoms.  

Avoid the temptation to ignore relatively minor side effects since they can escalate into much more serious complications rather quickly. While it may seem easy to dismiss a minor cough or slight bout of diarrhea, you should notify your doctor so he or she can determine if your symptoms are related to your treatment.

Sometimes patients are hesitant to report side effects because they’re scared their immunotherapy treatment will have to stop. Yet, remember when side effects are diagnosed early, treatment can often continue or only be delayed slightly. It’s when side effects become severe that your doctor will need to make a decision regarding whether it’s in your best interest to continue treatment.

Follow Your Doctor’s Orders

If your doctor prescribes a medication such as a steroid or an antibiotic to treat any side effect, make sure you take the full course as prescribed, even if you begin to feel better. Steroids, in particular, often require a slow taper over time. Discontinuing a medication too soon may result in a rebound effect, causing your symptoms to return.

Make Small Lifestyle Changes

There are also non-medical ways of coping with some of the most common side effects from immunotherapy.

For fatigue:

  • Schedule time to rest throughout the day and make sure to get a full night’s sleep.

  • Eat a nutrient-rich diet and stay well hydrated.

  • Incorporate regular, light exercise if approved by your doctor.

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Medical Reviewers: William C. Lloyd III, MD, FACS Last Review Date: Dec 23, 2016

© 2016 Healthgrades Operating Company, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades Operating Company, Inc. Use of this information is governed by the Healthgrades User Agreement.

View Sources

Medical References

  1. How to Treat Side Effects of New Cancer Immunotherapies. Medscape.
  2. Immunotherapy. Lungevity Foundation.
  3. Managing Side Effects of Immunotherapy: Diarrhea/Colitis. Medscape.
  4. Your Immune System and Lung Cancer Treatment. Cancer Support Community.

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